Arsenal and Liverpool will fancy their chances of making progress after landing ties against Crystal Palace and Southampton respectively in the quarter-finals.
The Gunners have not been at their brilliant best this season, but will be well backed on betting apps to defeat Palace at the Emirates Stadium.
Liverpool should also have little difficulty progressing to the semi-finals after being drawn against Premier League strugglers Southampton.
The tie of the round is undoubtedly the clash between Tottenham Hotspur and Manchester United, and both sides will fancy their chances of winning.
Spurs manager Ange Postecoglou is eager to win this competition having pointed out earlier in the season that he always lifts silverware in his second year at a club.
However, his hopes could be scuppered by Man United, who will be keen to make an impression under new manager Ruben Amorim.
Odds of 6/1 on UK betting sites for the Red Devils to claim the trophy for the second time in three seasons will tempt punters looking for a value bet.
Newcastle’s United’s reward for overcoming Chelsea is a home tie against Brentford and they are the favourites to reach the last four.
